Broadband amplifier for extra- and intracellular measurements

Broadband amplifier for extra and intracellular measurementsBroadband amplifier for extra and intracellular measurements

 

The unit is a broadband, low-noise amplifier, which is suitable for the amplification of intra-/extracellular potentials in the in-vivo conscious, in-vivo anesthetized and in-vitro tissue slice models (e.g.: cardiac MAP, nerve evoked potentials, etc. ). The high quality low/high-pass filters allow to mark the bands of the basic physiological signs (EEG, ECG, EMG, EGIG, etc.) and through which also the accurate transfer of the wave characteristics. The unit consists of two main parts, the low–noise, high input impedance pre-amplifier and the end-amplifier, which contains the high-slope band-pass and notch filters.

 

 

Specification

Broadband amplifier for extra- and intracellular measurements  
Amplification x102; 103; 104, calibrated with a pre-amplifier
Bandwidth DC, 20kHz
Noise CMMR<120dB
Calibration levels GND, 100% (for the adjustment of signal processing unit)
Offset adjustment ±1V related to the input
High-pass filter DC, 0.05; 0.1; 0.5; 1; 5; 10; 50; 100Hz / 80dB
Low-pass filter DC, 0.05; 0.1; 0.5; 1; 5; 10; 50; 100Hz / 80dB
Notch filter 50Hz 80db
Input impedance 10MΩ symmetric / 109Ω asymmetric
Output impedance 100Ω asymmetric
Input connector Mini banana socket (2mm)
Output connector 6,3 Jack
Power supply 110-220 V/12 V 1A DC adapter

Available models

EXP-EXT-1 Broadband amplifier (1-channel)

EXP-EXT-2 Broadband amplifier (2-channel)

EXP-EXT-4 Broadband amplifier (4-channel)

You can find the optional accessories by clicking here

Mini banana plug for symmetric/asymmetric connection (3pcs plug/pack)

SEN-15-XX Ag/AgCl electrodes (for details see SEN-15-K02 datasheet)

Glass electrodes

Metal electrodes

References

 Year  Author  Title  Source
1999 Domoki F, Veltkamp R, Bari F, Louis TM, Busija DW. Cerebrovascular reactivity remains intact after cortical depolarization in newborn piglets Pediatr Res. 1999 Jun;45(6):834-7.
2000 Köhn E. Dünn- und Dickdarmmotilität des Pferdes Hannover, Tierärztl. Hochsch., Diss., 2000
2001 Huang W, Kingsbury MP, Turner MA, Donnelly JL, Flores NA, Sheridan DJ. Capillary filtration is reduced in lungs adapted to chronic heart failure: morphological and haemodynamic correlates Cardiovasc Res. 2001 Jan;49(1):207-17.
2002 Zima E, Kékesi V, Nagy A, Losonczi L, Toma I, Soós P, Barát E, Huszár E, Merkely B, Horkay F, Juhász-Nagy A. Endothelin-1-induced elevations in purine metabolite concentrations ± autoregulatory protection in the canine pericardium Clin Sci (Lond). 2002 Aug;103 Suppl 48:202S-205S.
2003 Montaño LM, Carbajal V, Arreola JL, Barajas-López C, Flores-Soto E, Vargas MH. Acetylcholine and tachykinins involvement in the caffeine-induced biphasic change in intracellular Ca2+ in bovine airway smooth muscle Br J Pharmacol. 2003 Jul;139(6):1203-11.
2003 Hrbasová M, Novotny J, Hejnová L, Kolár F, Neckár J, Svoboda P. Altered myocardial Gs protein and adenylyl cyclase signaling in rats exposed to chronic hypoxia and normoxic recovery J Appl Physiol (1985). 2003 Jun;94(6):2423-32.
2004 Sári R, Pálvölgyi A, Rakonczay Z Jr, Takács T, Lonovics J, Czakó L, Szilvássy Z, Hegyi P. Ethanol inhibits the motility of rabbit sphincter of Oddi in vitro World J Gastroenterol. 2004 Dec 1;10(23):3470-4.
2006 Raghu KG. Effect of melittin on electrically driven action potential of guinea pig papillary muscle Journal of Cell and Tissue Research Vol. 6 (2) 749-752 (2006)
2008 López D, Rodríguez-Sinovas A, Agulló L, Inserte J, Cabestrero A, García-Dorado D. Acidic reoxygenation protects against endothelial dysfunction in rat aortic rings submitted to simulated ischemia Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2409-16. doi: 10.1152/ajpheart.00409.2008. Epub 2008 Oct 17.
2010 Radomirov R, Negrev N, Itzev DE, Stavreva G. Activation-dependent descending reflex evacuation of anal canal in a rat model Arch Ital Biol. 2010 Dec;148(4):377-88. doi: 10.4449/aib.v148i4.1200.
2012 Chu J, Miller CT, Kislitsyna K, Laine GA, Stewart RH, Cox CS, Uray KS. Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle Neurogastroenterol Motil. 2012 Mar;24(3):257-66, e109. doi: 10.1111/j.1365-2982.2011.01855.x. Epub 2012 Jan 11.
2013 Klarik Z, Toth E, Kiss F, Miko I, Furka I, Nemeth N. A modified microsurgical model for end-to-side selective portacaval shunt in the rat. Intraoperative microcirculatory investigations Acta Cir Bras. 2013 Sep;28(9):625-31.
2013 Broskova Z, Sotnikova R, Nedelcevova J, Bagi Z Effect of a novel stobadine derivative on isolated rat arteries Interdiscip Toxicol. 2013 Jun;6(2):63-6. doi: 10.2478/intox-2013-0011.
2014 Grześk G, Malinowski B, Grześk E, Wiciński M, Szadujkis-Szadurska K. Direct regulation of vascular smooth muscle contraction by mastoparan‑7 Biomed Rep. 2014 Jan;2(1):34-38. Epub 2013 Oct 4.
2014 Singh B, Sangle GV, Murugan J, Umrani R, Roy S, Kulkarni O, Semwal A, Unnikrishnan M, Jain M. Effect of combination treatment of S–amlodipine with peroxisome proliferator-activated receptor agonists on metabolic and cardiovascular parameters in Zucker fa/fa rats Diabetol Metab Syndr. 2014 Mar 28;6(1):45. doi: 10.1186/1758-5996-6-45.
2014 Sarika Singh,Sharad Sharma, C. Nath, Srikant Kumar Rath, R. K. Singh, Smrati Bhadauria, Poonam Singh, R.k. Shukla, Manoj Barthwal, M Dikshit Essential safety pharmacology and safety evaluation of bioactive fraction of Xylocarpus moluccensis an antidyslipidaemic agent  International journal of medical science and clinical Invention Volume 1 Issue 1 2014 page no. 24-47

Note: experiments were performed with differnet types of amplifiers.

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