Isolated Liver or Kidney Perfusion System

Liver or Kidney Perfusion System

MDE’s isolated liver and kidney perfusion systems provide researchers with a versatile and precise platform for studying organ function and pharmacology. By allowing precise control of perfusate composition, these systems support investigations into drug metabolism, organ responses, and physiological processes. 

The system is suitable for isolated liver or kidney perfusion, with two chamber sizes available to match the organ being studied. Organs are maintained horizontally in an evaporation chamber, preventing deformation of vasculature from twisting or weight. Unlike immersion-based setups, the organ is not submerged in buffer, avoiding extra hydrostatic pressure that could alter intravascular pressure or damage delicate vessels. 

MDE isolated liver or kidney perfusion system offers researchers a powerful tool for conducting sophisticated experiments in transplantation research, pharmacology, and organ physiology.

Key Advantages

  • Preservation of Organ Function: Horizontal placement ensures the organ’s vasculature remains intact, maintaining optimal function throughout experiments.

  • Prevention of Intravascular Pressure Build-Up: By avoiding immersion in liquid, the system keeps intravascular pressure low, especially important in liver perfusions, protecting hepatic vessels from injury.

  • Continuous Pressure Monitoring: Integrated software allows real-time monitoring of organ pressure, helping detect subtle changes and ensuring reliable experimental data. 

  • Versatile Applications: The system is ideal for testing the effects of drugs and toxins on organ vasculature and physiology, providing insights into pharmacological and toxicological mechanisms. 

  • Investigation of Organ Functions: Researchers can study hepatic metabolism, bile secretion, and urine production, enabling a comprehensive understanding of organ physiology.

  • Mitigation of Experimental Risks: Organ preparations are protected against thrombosis, embolism, and cardiovascular failure, common risks in in situ perfusions, ensuring consistent and reproducible results.

  • Controlled Perfusion and Temperature: Pump-controlled buffer flow and precise temperature regulation of both the perfusion fluid and evaporation chamber maintain optimal conditions for organ viability.

  • Sample Collection for Analysis: Low perfusate volumes make it easy to collect bile, urine, and organ-passed buffer fractions, facilitating qualitative or quantitative analysis of drugs, metabolites, or enzymes.